Development and characterization of pluronic lecithin organogel containing fluocinolone acetonide

The rabble-rousing skin condition can be conventionally treated, but due to some demerits, there is a need find novel approach with an appropriate release profile. research work narrates the optimization of topical delivery system Fluocinolone acetonide loaded in pluronic lecithin organogel. preliminary studies were carried out and, ternary phase diagram was established by Chemix school version 3.60. formulation optimized taking different concentration polymers as independent and viscosity drug (6 h) dependent variables applying 32 full factorial design. batch further compared marketed preparation also kept for stability study. profile exhibited sustained up 6 h (77.00%). It gave ex vivo (90.64%) which more prolonged than cutaneous disposition found higher. Besides, texture analysis that drug. However, proof effectiveness formulated organogel will require study future aspects. In nutshell, proposed fluocinolone simplest promising dosage form treatment psoriasis.